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[ESC2009]直接肾素抑制剂在降压和心肾保护方面的作用机理及临床表现--J R Gonzalez Juanatey教授专访
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 编辑:国际循环网 时间:2009/9/10 15:22:00    加入收藏
 关键字:直接肾素抑制剂 心肾保护 倍博特 阿利吉仑 

International Circulation: Could you discuss with us about the mechanism of direct renin and inhibition of anti-hypertension in cardio-renal protection?

国际循环:能否请您谈论一下直接肾素和抗高血压抑制在心肾保护中的机制?

Gonzalez Juanatey:  The plasma renin activity was closely related to vascular and kidney diseases.  This has seemed to be the case for years but recently a number of studies in post myocardial infarction (MI) patients and patients with chronic ischemic heart disease as well as hypertensive patients suggests that plasma renin activity is a marker and probably also is an important mechanism for removing vascular damage and kidney damage.  The problem is, at the present time, that we don’t have a drug to reduce or interfere with the plasma renin activity.  Plasma renin activity is a powerful risk factor for vascular and kidney dysfunction.

Gonzalez Juanatey教授: 血浆肾素活性与血管和肾脏疾病密切相关。虽然这一事实似乎是已知多年的,但是最近诸多在心肌梗死(MI)后患者和慢性缺血性心脏病以及高血压患者中进行的研究提示,血浆肾素活性是一种标记物,而且很可能也是消除血管损伤和肾脏损伤的重要机制之一。目前的问题是我们并没有降低或者干扰血浆肾素活性的药物。血浆肾素活性是血管和肾脏功能不全的一个强烈危险因素。

 

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