<International Circulation>:  It remains that late or very late stent thrombosis is a life-threatening complication after PCI with drug-eluting implantation. What measures can be taken to reduce the risk of late stent thrombosis?

  《国际循环》：PCI术后晚期或晚晚期支架内血栓是威胁生命的严重并发症，如何减少这种风险？
    Dr Kolansky: Late stent thrombosis is reduced by several mechanisms. First， it is important that the original stent implantation be done as well as possible， achieving good expansion and apposition of the stent to the wall. Also， the most important predictor for stent thrombosis is the failure to take thienopyridine medication， particularly clopidogrel， as directed， and the most effective measure to prevent stent thrombosis is to have patients remain on dual anti-platelet therapy consisting of a thienopyridine and aspirin for an extended period of time.

    Kolansky博士: 有很多方法可以避免晚期支架内血栓。其一：支架的妥善放置尤为重要，包括良好的扩张、位置和贴壁性。第二：支架内血栓的重要预测因素为：未合理使用噻吩吡啶类药物，如氯吡格雷。预防支架血栓最有效的方法是延长使用口服噻吩吡啶类药物加阿司匹林抗血小板治疗的时间。
    <International Circulation>: An extended period of time being……?

  《国际循环》：延长抗血小板治疗时间到什么时候为宜？
    Dr Kolansky: The current recommendations are generally at least one year for the use of aspirin plus thienopyridine and to continue aspirin indefinitely beyond that. There are ongoing studies looking at the use of dual anti-platelet therapy for greater than one year. The studies on those outcomes are not yet completed.

    Kolansky博士: 目前指南推荐阿司匹林+氯吡格雷服用至少一年，之后长期服用阿司匹林。也有研究强调强化抗血小板可以超过一年，但这些研究的预后还没有定论。

 

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